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KMID : 0385019960120010091
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Korean Journal of Laboratory Animal Science
1996 Volume.12 No. 1 p.91 ~ p.96
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Immunohistochemical Observation on Endocrine Cells of Pancreas in Mongolian Gerbil, Meriones Unguiculatus
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김용준/Kim, Yong Joon
이기훈/이철호/현병화/최양규/정규식/윤원기/Lee, Ki Hoon/Lee, Chul Ho/Hyun, Byung Hwa/Choi, Yang Kyu/Jeong, Kyu Shik/Yoon, Won Kee
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Abstract
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The regional distribution and shape of pancreatic endocrine cells in Mongolian gerbil was studied using immunohistochemical ABC method. The experimental results were summarized as the follows :
In hematoxylin and eosin stained sections, the islets of langerhans in Mongolian gerbil appeared to be round masses of cells staining less intensely than the surrounding acinar cells, and the endocrine cells of islets were generally round or oval-shaped, sometimes fusiform or wedge-shaped. These findings were similar to those of SD rat used as a control group.
In immunohistochemical observations, insulin (B3) eels were the most abundant cell type in the islet, located throughout the islet. Immunoreactivity of glucagon (A), somatostatin (D) and pancreatic polypeptide (PP) cells, mainly found in peripheral region of islet, were observed in sequence. By morphometry. D-cells were increased significantly, whereas A, FI and YP cells did not show a significant difference compared to control group (Student t test, p$lt;0.05), respectively. These results suggest that Mongolian gerbil has a difference in the composition of endocrine cells compared to that of rat. Further studies of endocrine system would be done in Mongolian gerbil for understanding these immunoreactivity.
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